Liraglutide (NN2211) is a long-acting glucagon-like peptide-1 receptor agonist, binding to the same receptors as does the endogenous metabolic hormone
GLP-1 that stimulates insulin secretion. Marketed under the brand name Victoza, it is developed by Novo Nordisk for the treatment oftype 2 diabetes. In 2015, Novo Nordisk began marketing it in the U.S. and E.U. under the brand name Saxenda
as a treatment for adults, who are obese or overweight with at least one weight-relatedcomorbid condition.
Liraglutide is a long-acting glucagon-like peptide-1 receptor agonist, binding to the same receptors as does the endogenous metabolic hormone GLP-1 that stimulates insulin secretion.
Product Name:
| Liraglutide
|
Other Name
| Liraglutide
|
CAS:
| 204656-20-2
|
MF:
| C172H265N43O51
|
MW:
| 486.42
|
Purity:
| 99%min
|
Shelf Life
| 2 years
|
Appearance
| White powder
|
Form
| Powder
|
Place of Origin:
| Shaanxi, China (Mainland)
|
Packaging:
| Bottle, Can, Drum, Plastic Contain
|
Standard:
| USP EP JP etc.
|
Specification:
Item
| Specification |
Appearance
| White Powder
|
Assay(HPLC)
| ≥99%
|
Solutility
| Insoluble in water and slightly soluble in ethanol and methanol
|
| Identification a)1H-NMR b)Retention time(HPLC) | Conforms to standard Conforms to standard
|
Melting point
| 275.0-286.0°C
|
Water Content(KF)
| 2.8-4.2%
|
Residue on ignition
| ≤0.2%
|
Heavy metals
| ≤20ppm
|
| Related substances Any single impurities Total impurities | ≤0.5% ≤1.0% |
1.Liraglutide acts in a glucose-dependent manner, meaning it will stimulate insulin secretion only when blood glucose levels are higher than normal, preventing "overshoot". Consequently, it shows negligible risk of hypoglycemia.
2.Liraglutide has the potential for inhibiting apoptosis and stimulating regeneration of beta cells (seen in animal studies).
3.Liraglutide decreases appetite and inhibits body weight gain, as shown in a head-to-head study glimepiride.
4.Liraglutide lowers blood triglyceride levels.
Liraglutide has been approved as an injectable adjunct to a reduced-calorie diet and increased physical activity for chronic
weight management in adult patients. The specified criteria are an initial body mass index (BMI) of 30 kg/m2 or greater (obese),
or 27 kg/m2 or greater (overweight), in the presence of at least one weight-related comorbid condition (e.g.hypertension, type 2 diabetes mellitus, or dyslipidemia). In late 2014, data were reported from the SCALE™ Obesity and Prediabetes trial, which is a randomised, double-blind, placebo-controlled, multinational trial in non-diabetic people with obesity and non-diabetic people who are overweight with comorbidities. In this phase 3a trial, there were 3,731 participants randomised to treatment with liraglutide 3 mg or placebo, both in combination with diet and exercise. Those who completed the 56-week trial achieved an average weight loss of 9.2%, to be compared with a 3.5% reduction in the placebo group.
Pyridoxamine dihydrochloride is a derivative of Vitamin B6. It has Antioxidant and anti glycosylation activities, which can help protect the eyes, kidneys, and nervous system from chronic disease damage. In addition, Pyridoxamine Dihydrochloride has also been used in some related research and clinical trials.
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