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Capsule & Tablet

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Sildenafil is a selective inhibitor of cyclic guanosine monophosphate (CGMP) - specific phosphodiesterase 5 (PDE5) and an oral drug for the treatment of ED. The physiological mechanism of normal penile erection involves the release of nitric oxide (no) during sexual stimulation. Nitric oxide activates guanylate cyclase in the smooth muscle cells of the corpus cavernosum, which leads to the increase of cGMP level, resulting in the relaxation of the smooth muscle in the corpus cavernosum, the expansion of the cavernous sinus and the inflow of blood. Erectile dysfunction is mainly due to the dysfunction of smooth muscle relaxation of corpus cavernosum. Sildenafil has no direct relaxation effect on human sponges in vitro, but can enhance the effect of nitric oxide by inhibiting the decomposition of cGMP by PDE5 in sponges. Sildenafil can inhibit PDE5, increase cGMP level, relax smooth muscle of corpus cavernosum and let blood flow into corpus cavernosum. Studies have shown that erectile response increases with the increase of dose and plasma concentration, and the efficacy can last for 4 hours (but is weaker than that at 2 hours).
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