Mildronate is a new type of cardioprotective drug, which can inhibit carnitine dependent fatty acid oxidation. Relax vascular smooth muscle, dilate vascular smooth muscle and coronary artery, reduce myocardial oxygen consumption and blood lipid. It can improve myocardial energy metabolism, also known as cellular anti ischemic drugs. Midroxazide can improve the loss of SERCA2 and hexokinase I caused by myocardial infarction, so as to reduce the tissue damage caused by myocardial ischemia and alleviate the hemodynamic dysfunction. It can regulate carnitine dependent fatty acid metabolism under ischemia, making it significantly different from other fatty acid oxidation inhibitors.
| Product name | Mildronate |
| CAS no. | 76144-81-5 |
| Molecular Formula | C6H14N2O2 |
| Molecular Weight | 146.18756 |
| Brand Name | Senwayer |
Met-88(also known as THP, MET-88 and mildronate) is a novel cardioprotective agent.
Met-88 acts on mitochondria at the cellular level to improve myocardial energy metabolism. In view of these drugs and other anti-myocardial ischemia significantly different, also known as cell anti-ischemic drugs. Met-88 is a structural analog of carnitine that competes in the inhibition of butyrate betaine hydroxylase, thereby inhibiting the biosynthesis of carnitine, which directly inhibits the transport of carnitine-dependent fatty acids in mitochondria. Inhibition of carnitine biosynthesis can reduce the concentration of intracellular free carnitine and prevent isoproterenol-induced acyl carnitine accumulation. Therefore, the drug has a significant protective effect on the myocardium, resulting in this protective effect at the same time on the hemodynamic parameters had no significant effect, cardiac blood supply and cardiac oxygen consumption was no significant change.
1. Met-88powder is a novel cardioprotective agent.
2.Met-88 acts on mitochondria at the cellular level to improve myocardial energy metabolism. In view of these drugs and other anti-myocardial ischemia significantly different, also known as cell anti-ischemic drugs.
3. Met-88 is a structural analog of carnitine that competes in the inhibition of butyrate betaine hydroxylase, thereby inhibiting the biosynthesis of carnitine, which directly inhibits the transport of carnitine-dependent fatty acids in mitochondria. Inhibition of carnitine biosynthesis can reduce the concentration of intracellular free carnitine and prevent isoproterenol-induced acyl carnitine accumulation.
Therefore, the drug has a significant protective effect on the myocardium, resulting in this protective effect at the same time on the hemodynamic parameters had no significant effect, cardiac blood supply and cardiac oxygen consumption was no significant change.
Minoxidil Powder, known as 6 - (1-piperidinyl) - 2,4-pyrimidine diamine-3-oxide, is an organic compound with white or almost white crystalline powder. It can directly relax vascular smooth muscle, has a strong role in small artery dilation, reduces peripheral resistance and blood pressure, and has no effect on volume vessels, so it can promote venous reflux. Antihypertensive drugs for refractory, primary or renal hypertension. It is used to prevent fat hair loss and animal husbandry.
Gabapentin Powder is a white to grayish white crystalline powder with stable chemical properties at normal temperature and pressure. It is an additional treatment for epilepsy patients with localized seizures which can not be satisfactorily controlled or tolerated by conventional antiepileptic drugs and epilepsy patients with localized seizures and then generalized.
Berberine Hydrochloride is mainly used in the treatment of gastroenteritis, bacillary dysentery and other intestinal infections, eye conjunctivitis, suppurative otitis media, etc. Recently, it has been found that this product has blocking effect α- Receptor, antiarrhythmic effect.
Nmn Powder(nicotinamide mononucleotide): full name“ β- Nicotinamide mononucleotide "is a kind of naturally occurring biologically active nucleotide. The decline of NAD in aging process is considered to be the main cause of disease and disability, such as hearing and vision loss, cognitive and motor dysfunction, immune deficiency, arthritis, metabolic disorder and cardiovascular disease caused by autoimmune inflammatory reaction disorder. Therefore, NMN supplementation can increase the content of nad+ in vivo, thus delaying, improving and preventing aging related phenotypes, or age-induced metabolic disorder, aging diseases, etc.Pregabalin Powder is an antiepileptic drug, is mainly used in the treatment of postherpetic neuralgia.
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