Orlistat is a non central nervous system obesity drug. It only acts on the gastrointestinal tract, prevents the hydrolysis of triglyceride to free fatty acids and monoacylglycerides by inhibiting the lipase in the gastrointestinal tract, reduces the absorption of dietary fat (triglyceride) by intestinal mucosa, and promotes the elimination of fat from the body. Lipase is an essential enzyme for the gastrointestinal tract to decompose fat. This product can combine with serine residues of gastric and pancreatic lipases to inactivate lipase, prevent it from decomposing fat in food into free fatty acids, inhibit the utilization and absorption of fat. In addition, this product can also reduce the risk factors related to obesity.
Indications:
Long term treatment for obese and overweight patients with moderate diet control and exercise, including patients with obesity related risk factors.
Clinical application:
Oral administration: the recommended dose is 120mg per meal or one hour after meal. If one meal is not taken or the food does not contain fat, one dose can be omitted.
Adverse reactions:
Common gastrointestinal reactions: oily spots, increased gastrointestinal exhaust, stool urgency, fatty stool, fatty diarrhea, increased stool frequency, fecal incontinence, abdominal pain / discomfort, watery stool, soft stool, rectal pain / discomfort.
Rare adverse reactions were upper respiratory tract infection, lower respiratory tract infection, influenza, headache, menstrual disorder, anxiety, fatigue, and urinary tract infection.
Rare adverse reactions: hypersensitivity reactions, such as pruritus, rash, urticaria, angioneurotic edema, bronchospasm and allergic reactions; Liver transaminase increased, liver failure.
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