What is Sildenafil citrate?
Multi-purpose Sildenafil citrate is a drug, chemical name is 1-[4-ethoxy-3 -[5-(6, 7-dihydro-1-methyl-7-oxo-3-propyl - 1h-pyrazole and [4,3d] pyrimidine)] benzene sulfonyl] -4-methylpiperazine citrate, is a white powder.
This product is used to treat erectile dysfunction (ED) orally. It is the citrate of Multipopulation applicability Sildenafil citrate, a selective inhibitor of cyclic guanosine phosphate (cGMP) specific type 5 phosphodiesterase (PDE5). Mechanism of action: The physiological mechanism of penile erection involves the release of nitric oxide (NO) in the penile sponge during sexual stimulation. NO activation of guanylate cyclase leads to increased levels of cyclic guanosine phosphate (cGMP), which can relax smooth muscle and fill blood in sponges.
Role of High Quality Sildenafil citrate in penile erectile response: Multipopulation applicability Sildenafil citrate is a highly selective phosphodiesterase 5 (PDE5) inhibitor. PDE5 is highly expressed in the corpus cavernosa of the penis, but is poorly expressed in other tissues, including platelets, blood vessels and visceral smooth muscle and skeletal muscle. High Quality Sildenafil citrate selectively inhibits PDE5, enhances the nitric oxide (NO) -cGMP pathway, and increases cGMP level, which leads to the relaxation of smooth muscle of the corpus cavernosa, resulting in a natural erectile response in patients with erectile dysfunction to sexual stimulation. Erectile response was generally enhanced with the increase of sildenafil dose and plasma concentration. Experiments showed that the effect lasted up to 4 hours, but the response was weaker than that at 2 hours. Sildenafil's reaction to myocardium: No PDE5 was present in normal or diseased heart conduction tissues, cardiomyocytes, endothelial cells, and lymphoid tissues. Therefore, High Quality Sildenafil citrate (PDE5 inhibitor) had no positive inotropic effect and could not directly affect myocardial systolic function.
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