Orlistat is a non-systemic effects of anti-obesity drugs for specific gastrointestinal lipase inhibitor, combined with dietary restrictions can help promote weight loss and prevent weight regain. Gastrointestinal lipases break down fats in the gastrointestinal tract is necessary enzymes, orlistat inhibits stomach, pancreatic and hydroxy acid esterase, primarily through the stomach, small intestine lumen of the stomach and pancreatic lipases active serine parts form a covalent bond, to inactivate enzymes play a therapeutic role.
| Product name | Orlistat |
| Cas | 96829-58-2 |
| Brand | Iknow |
| Appearance | White Powder |
| Specification | 99% |
| Type | Raw Materials |
| Package | 1Kg/25Kg/Drum or As per your request |
| Storage | Store in cool and dry places ,keep away from strong light |
| Shelf life | 2 years when properly stored |
| Safety | Non-toxic, non-stimulating, safe and reliable |
Tetrahydrolipstatin (orlistat) is a semi-synthetic derivative of lipstatin, a metabolite isolated from Streptomyces toxytricini. Tetrahydrolipstatin acts as a potent, irreversible inhibitor of pancreatic lipase. In vivo, it blocks the absorption of triglycerides while allowing fatty acid absorption. Tetrahydrolipstatin is widely used for the treatment of obesity.
Specification:
| Item | Specification | Result |
| Appearance | while powder | white powder |
| Identification | HPLC retention time | Conforms |
| Melting Point | 42 ºC -45°C | 42 ºC -45°C |
| Specific optical rotation | -31.0°~-41.0° | -36.0° |
| Purity optical rotation | -31.0°~-41.0° | -36.0° |
| Total impurity | no more than 2.0% | 1.6% |
| Max Individual impurity | no more than 0.5% | 0.3% |
| Water content%(K&F) | no more than 0.5% | 0.1% |
| Residual solvents | EtOH no more than 0.5% | N.D |
| EtAC no more than 0.5% | N.D |
| n-Heptane no more than 0.5% | less than 0.1% |
| Residue on ignition | less than 0.2% | 0.10% |
| Heavy metals | no more than 20ppm | less than20ppm |
| Assay (HPLC) | no less than 99.0% | 99.60% |
| Conclusion | Meets the Requirements |
1) Orlistat is used with a low-calorie diet to help you lose weight and to maintain your weight after weight loss.
2) Orlistat is in a class of drugs called lipase inhibitors. It works in your intestines, where it blocks some of the fat you eat from being absorbed and digested. This undigested fat is then removed in your bowel movements .
3) Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake. It is intended for use in conjunction with a healthcare provider-supervised reduced-calorie diet.
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