Oxytetracycline is an organic substance with the chemical formula of c22h24o9n2. It is a light yellow crystalline powder, slightly soluble in ethanol and very slightly soluble in water. It is stable in the air and darkens when exposed to light. Oxytetracycline belongs to acid-base amphoteric substance, which can combine with acid or alkali to form salts. It is very slightly soluble in water and is easily soluble in dilute alkali and dilute acid. Oxytetracycline salt is easy to be damaged and ineffective in alkaline aqueous solution and is relatively stable in acidic aqueous solution.
Purpose
It can be used to treat respiratory tract, urethra, skin and soft tissue infections in dogs and cats, including brucellosis, Rickettsia and Chlamydia in dogs, colibacillosis in dogs and cats, infectious anemia caused by Rickettsia in cats, and also to prevent leptospirosis in dogs.
Pharmacological Action
Oxytetracycline has broad-spectrum antiviral effect on microorganisms. It is a rapid bacteriostatic agent. It has bactericidal effect on some bacteria at high concentration. Its mechanism is that the drug can specifically bind to the a position of ribosomal 30S subunit and prevent the connection of aminoacyl tRNA at this position, so as to inhibit the growth of peptide chain and affect the protein synthesis of bacteria or other pathogenic microorganisms. Oxytetracycline has strong antibacterial activity against Staphylococcus aureus, pneumococcus, Streptococcus pyogenes, Neisseria gonorrhoeae, meningococci, Escherichia coli, aerogenic bacteria, Shigella, Yersinia and Listeria monocytogenes; In addition, oxytetracycline also has strong effects on Rickettsia, mycoplasma, chlamydia and actinomycetes.
Indication
1. Oxytetracycline can be used as an optional drug for the treatment of the following diseases: (1) Rickettsia disease, including epidemic typhus, endemic typhus and tsutsugamushi disease (2) Mycoplasma pneumoniae infection (3) Chlamydia infection, including psittacosis, inguinal granuloma (venereal lymphogranuloma), nonspecific urethritis, salpingitis and trachoma（ 4) Regressive fever (5) Brucellosis (in combination with aminoglycosides) (6) Cholera (7) plague (combined with aminoglycoside drugs); (8) Rabbit fever 2. Oxytetracycline can be used to treat tetanus, gas gangrene, Yasi, syphilis, gonorrhea and leptospirosis allergic to penicillin antibiotics. 3. Oxytetracycline can also be used to treat respiratory tract, biliary tract, urinary tract, skin and soft tissue infections caused by sensitive bacteria 4. Oxytetracycline can also be used in the treatment of acne.
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