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July 22, 2021
Quinine, also known as cinchonine, molecular formula is C20H24N2O2, is the main alkaloid in the bark of Rubiaceae plant cinchona and its homologous plants. It is a kind of drug for the treatment and prevention of malaria and for the treatment of charcosis.
Chinese Name: quinine
Other Name: Cinchonine
English Name: quinine
CAS No.: 130-95-0
MDL No.: mfcd00198096
EINECS No.: 205-003-2
RTECS No.: va6020000
BRN: 91867
PubChem: 24848751
Molecular formula: C20H24N2O2
Molecular weight: 324.417
Purpose
Quinine is an important antimalarial drug because it can inhibit the reproduction of Plasmodium falciparum. Quinine can also inhibit myocardial contractility and increase uterine rhythmic contraction.
Pharmacological Action
This drug is a quinoline derivative, which has strong killing effect on the erythrocytic schizonts of various Plasmodium. This drug can combine with DNA of Plasmodium to form complex, inhibit DNA replication and RNA transcription, thus inhibit protein synthesis of Plasmodium, but its effect is weaker than that of chloroquine. The drug can also reduce the oxygen consumption of Plasmodium, inhibit the phosphorylase in Plasmodium and interfere with its glucose metabolism. The drug also causes malarial pigment agglutination, but the development is slow, rarely forming large lumps. In the blood, a certain concentration of this drug can lead to premature rupture of the parasitized red blood cells, thus preventing the schizonts from maturing. This drug is not effective in the treatment of benign malaria. Long course of treatment can cure Plasmodium falciparum, but it has no direct effect on Gametophyte of Plasmodium falciparum, so the transmission can not be interrupted. In addition, the drug can inhibit the myocardium, prolong the refractory period, slow down the conduction and weaken its contractile force. It has weak excitatory effect on pregnant uterus.
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