Ursodeoxycholic acid can reduce cholesterol and cholesterol in bile, which is conducive to the gradual dissolution of cholesterol in gallstones.
Purpose
It is used to treat gallstones, cholestatic liver diseases, fatty liver, various types of hepatitis, toxic liver disorder, cholecystitis, cholangitis, biliary dyspepsia, bile reflux gastritis, eye diseases, etc.
Pharmacological action
1. Increase the secretion of bile acid, lead to the change of bile acid composition, increase its content in bile and have cholagogic effect. The mean value of bile acid secretion increased from 1.8 mmol per hour to 2.24 mmol. Long term administration could increase the content of UDCA in bile without increasing the content of bile acid.
2. It can inhibit the synthesis of cholesterol in the liver, significantly reduce the amount of cholesterol and cholesterol esters in bile and the saturation index of cholesterol, which is conducive to the gradual dissolution of cholesterol in stones. In addition, UDCA can promote the formation of liquid cholesterol crystal complex, which can accelerate the excretion and clearance of cholesterol from gallbladder to intestine.
3. Relax the sphincter of Oddi, which has a cholagogic effect.
4. Reduce liver fat, increase the activity of liver hydrogen peroxidase, promote the accumulation of liver glycogen, and improve the anti-toxic and detoxification ability of liver.
5. It can reduce the concentration of triacylglycerol in liver and serum.
6. Inhibit the secretion of digestive enzymes and digestive juice.
7. Foreign studies have also shown that ursodeoxycholic acid has immunomodulatory effect in chronic liver diseases, can significantly reduce the expression of HLA class antigens in hepatocytes and reduce the number of activated T cells. Ursodeoxycholic acid is better than chenodeoxycholic acid (CDCA) in dissolving cholesterol stones in vivo.
indication
1. It is suitable for non calcified stones with normal gallbladder function, light transmission and diameter of 10 ~ 15mm.
2. Prevention of gallstone formation: ursodeoxycholic acid can be taken to prevent gallstone formation for patients who need long-term use of drugs easy to form cholesterol stones (such as estrogen, clofibrate and its derivatives, colenemide), long-term consumption of high cholesterol diet, or those with susceptible genetic factors.
3. Treatment of cholecystitis, cholangitis, biliary dyspepsia, jaundice, etc.
4. It can be used to treat fatty diarrhea, hypertriglyceridemia, hepatomegaly and chronic hepatitis after ileectomy. It can also be used for bile reflux gastritis.
5. It is also used for primary biliary cirrhosis and primary sclerosing cholangitis.
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