The main active components of Fructus Cnidii extract include pinene, camphene, Bornyl isovalerate, isoborneol, methoxyeugenol, cindimine, cnidiadin, isopimpinelline, etc.
Pharmacological Efficacy
Osthol has antispasmodic, hypotensive, antiarrhythmic, enhancing immune function and broad-spectrum antibacterial effects. Warming the kidney, strengthening yang, drying dampness, dispelling wind and killing insects. For impotence, palace cold, infertility, cold and wet belt, wet nose and low back pain; External treatment: eczema of vulva, vaginal itching of women, trichomonal vaginitis
Pharmacological Action
1. Effect of antiviral microorganism. Fructus Cnidii has inhibitory effect on Trichophyton flocculus, Bacillus gypsum like and Bacillus wool in test tube. It can prolong the life of chicken embryo by 6 hours for Newcastle virus cultured in chicken embryo. Fructus Cnidii extract (1:2) has strong killing effect on Trichomonas vaginalis in vitro. However, it has also been reported that liver extract is used as culture medium, 10% and 20% Fructus Cnidii decoction had no or very weak killing effect on Trichomonas vaginalis
2. Sex hormone like effect. Continuous subcutaneous injection of ethanol extract of Fructus Cnidii for 32 days can prolong the estrous period, shorten the estrous interval, make the ovaries and uterus of ovariectomized mice appear estrous period, and increase the weight of prostate, seminal vesicle and levator ani muscle (mice), Osthol extract has androgen - like effect and no corrosive effect on rabbit vaginal mucosa.
3. Antiarrhythmic effect the aqueous extract of Fructus Cnidii has preventive effects on chloroform induced ventricular fibrillation in mice, calcium chloride induced ventricular fibrillation in rats and aconitine induced arrhythmia in rats, and has obvious therapeutic effect on the latter. This shows that the aqueous extract of Fructus Cnidii has antiarrhythmic effect. It can effectively resist aconitine and promote the opening of sodium channel Accelerate the ectopic rhythm of Na + influx, suggesting that the aqueous extract of Fructus Cnidii can significantly inhibit the influx of Na + and Ca + + in cardiomyocyte membrane, so as to play an anti arrhythmia role.
4. The study on the effect of Osthol on the respiratory system shows that Osthol has a strong bronchodilator effect. Osthol can increase the pulmonary perfusion flow of guinea pigs, and its effect is stronger than aminophylline. Total coumarin of Osthol is administered by gavage to guinea pigs, It can prolong the attack time of asthma in guinea pigs caused by histamine phosphate and acetylcholine chloride. In vitro experiments show that Osthol total coumarin has a strong antagonistic effect on histamine induced tracheal contraction in isolated guinea pigs. The above effects can be blocked by propranolol and have no effect on heart rate and blood pressure in anesthetized animals, suggesting that Osthol total coumarin may selectively excite bronchial smooth muscle β 2 receptor, producing antispasmodic and antiasthmatic effects. Intragastric administration of total coumarin from Fructus Cnidii to mice can significantly increase the excretion of phenol red, suggesting that this product has a strong expectorant effect.
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