Aesculin a Inhibiting the Growth of Bacillus Subtilis

July 06, 2021

Esculin is a bitter. Naringin dihydrochalcone obtained by hydrolysis and hydrogenation is a Sweetener, and its sweetness is about 150 times that of sucrose. It has anti-inflammatory, antibacterial, anti hemagglutination, analgesic and other activities, and has significant diuretic effect on mice. It can inhibit the aldose reductase of rat lens, and it is the growth inhibitor of Bacillus subtilis. At the same time, it can also inhibit the chemical carcinogenesis.

Esculin

Pharmacological Action

1. Anti inflammatory and analgesic effects: intraperitoneal injection of 10mg / kg in rats inhibited carrageenan induced arthritis, dextran induced arthritis, serotonin induced arthritis and histamine induced arthritis with the inhibition intensity of 35%, 28%, 20% and 8% respectively; It can inhibit the formation of granuloma in rats (cotton ball method), erythema reaction induced by ultraviolet radiation on the back of guinea pigs, and the increase of capillary permeability induced by histamine. It has a weak analgesic effect.
Esculin2
2. Effect on urine output and uric acid excretion: all kinds of administration routes can enhance the uric acid excretion of rats and rabbits, and have no diuretic effect on normal rats, but have significant diuretic effect on mice. 3. Others: antibacterial, anticoagulant and inhibition of aldose reductase in rat lens.

98 Esculin Jpg

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