S-adenosyl-L-methionine. S-adenosyl-L-methionine, commonly referred to as SAMe, is a naturally occurring compound in the human body. SAMe is a Nucleophilic substitution that participates in a variety of biosynthetic and metabolic processes in the human body. It is composed of a combination of adenosine ring, aminomethyl ring, and thiomethyl ring, so its name can be distinguished from three aspects: "S-adenosine", "L-methionine", and "methyl". SAMe can transfer methyl groups and participate in various metabolic pathways in the body. For example, SAMe can provide substrates for important molecules such as proteins, nucleotides, and phospholipids in liver cells, and can also provide necessary methyl groups for DNA and RNA methylation. In addition, SAMe can also regulate a variety of metabolic pathways, such as methionine metabolism, single Carbon cycle metabolism and sulfate metabolism.
S-Adenosyl methionine(SAMe) is a common cosubstrate involved in methyl group transfers. SAMe was first discovered in Italy by G. L. Cantoni in 1952, SAMe is a molecule produced constantly by all living cells,can preventing liver cancer, promoting cartilaginous tissue forming and concrescence, may help fight depression, alzheimer's disease, liver disease, and the pain ofosteoarthritis.
SAME with 99% purity and lowest price, we also can make capsules according customer's request.
| Product Name: S-Adenosyl Methionine Other Name: SAMe CAS: 29908-03-0 MF:C15H22N6O5S MW:398.44 2-8 ℃, it is very easy to absorb moisture
Grade Standard: Medicine Grade 
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Specification: | ANALYSIS | SPECIFICATION | RESULT |
| Appearance | White powder | Complies |
| Odor & Taste | Characteristic | Complies |
| Identification | Infrared: Conforms to the reference spectrum HPLC: The rotention time of the major peak corresponds to the reference sample | Complies |
| Assay | 99% | Complies |
| Sieve Analysis | 100% pass 80 mesh | Complies |
| Loss on Drying | 5.0% Max | 1.02% |
| Sulphated Ash | 0.5% Max | Complies |
| PH (5% Aqueous Solution) | 1.0-2.0 | 1.2 |
| S,S-Isomer(HPLC) | 75% Min | 82% |
| SAM-e ION(HPLC) | 49.5%-54.7% | 52% |
| P-Toluenesulfonic Acid | 21.0%-24.0% | 22.5% |
| Sulfate(HPLC) | 23.5%-26.5% | 25.4% |
| S-Adenosyl-l-Methionine Disulfate Tosylate | 95%-103% | 99.9% |
| Related Substances | | |
| S-Adenosyl-l-Homocysteine | 1.0% Max | 0.1% |
| Adenine | 1.0% Max | 0.2% |
| Methylthioadenosine | 1.5% Max | 0.1% |
| Adenosine | 1.0% Max | 0.1% |
| Total Impurities | 3.5% Max | 1.0% |
| Bulk Density | 0.5g/ml | Complies |
| Heavy Metal | 10ppm Max | Complies |
| As | 2ppm Max | Complies |
| Microbiology | | |
| Total Plate Count | 1000/g Max | Complies |
(1) Transfer Methyl
SAMe can transfer methyl groups and participate in various metabolic pathways in the body. For example, SAMe can synthesize important molecules such as proteins, nucleotides, and phospholipids for liver cells, and provide substrates for DNA and RNA methylation.
(2) Antioxidant effect
SAMe has a certain antioxidant effect, which can eliminate free radicals in the body, reduce oxidative damage, and thus protect human health.
(3) Balanced neurotransmitters
SAMe can balance the distribution of neurotransmitters in the human body, regulate the function of the nervous system, and improve performance in various aspects such as mood, sleep, cognition, and exercise.
(4) Improve joint pain
SAMe can also alleviate joint pain and inflammation, and is an effective method for treating diseases such as osteoporosis and arthritis.
(5) Promoting liver health
SAMe helps maintain the normal structure and function of liver cells, preventing liver damage and diseases such as hepatitis.
1.SAMe is a good nutrition for the liver,can prevent alcohol, drugs and the liver-cell injury.
2.SAMe has remarkable preventiveeffects on chronic active hepatitis, and other factors caused liver injury,heart disease, cancer and so on.
3.SAMe has been found to be as effective as pharmaceutical treatments for arthritis and major depression as well.
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