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Tetracaine hydrochloride is a highly effective local anesthetic that can block nerve function reversibly. It is used in infiltration anesthesia, nerve block anesthesia, epidural anesthesia, etc. compared with procaine, its local anesthesia effect is significant, and has been widely used in clinic. Through studying the existing synthesis routes, it is found that the synthesis of intermediate p-butylamino benzoic acid is the key step in the synthesis of tetracaine hydrochloride, which has the shortcomings of unstable raw materials or low yield. Scientists have improved this. In 1981, they proposed to synthesize p-butylamino benzoic acid by alkylating p-aminobenzoic acid with 1-Bromobutane. However, due to the inevitable formation of by-products of dibutylation and the unstable nature of raw materials, this route is not suitable for industrial production.
Purpose:
This product is a long-acting ester local anesthetic. Its action characteristics are: strong penetration to mucosa, suitable for surface anesthesia, and no adverse reactions such as vasoconstriction, mydriasis, corneal injury after eye drops. It is commonly used in ophthalmology. The local anesthetic effect and toxicity are about 10 times greater than procaine. After injection, the intoxication of hemp chemicalbook appeared slowly (about 10 minutes), and the metabolism was also slow after absorption. The local anesthesia time was up to 3ij, h, -j. about. It is mainly used for surface anesthesia of eye, nose and throat mucosa, and rarely used for conduction anesthesia and epidural anesthesia. Generally, it is not used for infiltration anesthesia due to its high toxicity.
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