It mainly acts on 5-HT system, without excitation, sedation, anti acetylcholine and cardiac toxicity. For depression.
Pharmacological Action
The results also showed that tianeptine was also effective on anxiety symptoms, and the score reduction rate of HAMA at the end of the 6th week was slightly higher than that of amitriptyline, which was consistent with the literature report. In conclusion, the results showed that tianeptine had positive antidepressant effect, less adverse reactions and mild degree. The patient has good tolerance and high compliance, which is suitable for clinical application.
Other studies have shown that tianeptine can improve childhood asthma. Researchers in Venezuela and the United States reported that tianeptine can suddenly and dramatically improve clinical severe asthma.
The antidepressant mechanism of this product is different from traditional TCA. It can increase the uptake of 5-HT in synaptic space, and has weak effect on the reuptake of 5-HT and Na. It may improve the transmission of 5-HT neurons. For M receptor, H1 α 1 and α 2-NA receptors have no affinity.
The antidepressant efficacy of this product is similar to TCA, and its safety and tolerance are better than TCA (tricyclic antidepressants). The efficacy of this product is similar to that of fluoxetine of SSRI.
Animal drug experiments show that it can increase the spontaneous activity of hippocampal pyramidal cells and accelerate the recovery of their function after inhibition; Increase the reabsorption of serotonin by neurons in cerebral cortex and hippocampus.
Characteristics of tianeptine in human body:
It has a certain effect on mood disorders. As a classification of antidepressants, this drug is between sedative antidepressants and excitatory antidepressants;
It has obvious effect on physical discomfort, especially gastrointestinal discomfort symptoms related to anxiety and mood disorder;
It has a certain effect on the personality and behavior disorders of alcoholism patients during abstinence.
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