NMN (nicotinamide mononucleotide): full name“ β- Nicotinamide mononucleotide "is a naturally existing bioactive nucleotide. There are two irregular forms of NMN, α and β；β The isomer is an active form of NMN, with a molecular weight of 334.221g/mol.
The decline of NAD during aging is considered to be the main cause of diseases and disabilities, such as hearing and vision loss, cognitive and motor dysfunction, immune deficiency, arthritis, metabolic disorders and cardiovascular diseases caused by autoimmune inflammatory response disorder. Therefore, the supplement of NMN can increase the content of NAD + in vivo, so as to delay, improve and prevent a variety of aging related phenotypes, or age-induced metabolic disorders and senile diseases.
Since the discovery of NAD + in 1906, scientists have paid close attention to NAD + because of its abundance in human body and its key role in the molecular pathway of maintaining human body function. In animal studies, increasing the level of NAD + in vivo has shown encouraging results in the fields of metabolism and age-related diseases, and even some anti-aging properties. Age related diseases such as diabetes, cardiovascular disease, neurodegeneration and immune system generally decline.
As adults grow up, the immune system declines, people are more likely to get sick, and it is more difficult for people to recover from seasonal influenza or even covid-19. Recent studies have shown that NAD + levels play an important role in regulating inflammation and cell survival during immune response and aging. This study highlights the therapeutic potential of NAD + for immune dysfunction[ 1]
Statistics show that the proportion of adults infected with covid-19 is not proportional. About 13.4% of patients aged 80 years or above died of cowid-19, while 1.25% and 0.06% of patients in their 50s and 20s died of cowid-19, respectively. A recent Oxford University study, which analyzed 17.4 million British adults, showed that age was the most important risk factor associated with death from cowid-19. Other risk factors include men, uncontrolled diabetes and severe asthma.
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