Levodopa, a precursor of dopamine (DA), has no pharmacological activity. It enters the center through the blood-brain barrier and is transformed into DA by dopa decarboxylase.
Indication
The effect of improving myotonia and bradykinesia is obvious. Continuous medication is also effective for tremor, salivation, postural instability and dysphagia.
1. Parkinson's disease (primary tremor paralysis)
Symptomatic Parkinson's syndrome (non drug-induced tremor paralysis syndrome) after encephalitis or combined with cerebral arteriosclerosis and carbon monoxide and manganese poisoning of the central nervous system. It can reduce the symptoms of tremor paralysis, improve muscle tension and make limb activities more normal. The effect is better for patients with mild and moderate disease, and worse for patients with severe or elderly disease.
2. Hepatic encephalopathy
It can make patients awake and improve symptoms. Hepatic encephalopathy may be related to the abnormality of central transmitter dopamine. After taking it, it can improve central function. Others believe that levodopa can improve brain tolerance to ammonia, but can not improve liver injury and liver function.
3. Neuralgia
Early use can relieve neuralgia.
4. Hyperprolactinemia
It can inhibit thyrotropin releasing hormone in hypothalamus and excite prolactin releasing inhibitory factor, so as to reduce prolactin secretion. It is used to treat hyperprolactinemia and has a certain effect on galactorrhea.
5. Depilation
The mechanism may be to increase the catecholamine concentration from blood to tissue and promote hair growth.
6. Promote the growth and development of children
It can accelerate the growth and development of children's bones by promoting the secretion of growth hormone. Treat children with hypophysis.
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