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February 14, 2022
Molecular weight: 531.59500
pharmacological action
This product is an alkaloid extracted from Cephalotaxus or its congeners in Cephalotaxus family. Can inhibit DNA polymerase α The activity of and the synthesis of nuclear protein lead to the disorder of DNA synthesis. It is a cell cycle nonspecific drug, which has a strong killing effect on S-phase cells and has a certain effect on G0 phase cells. It can inhibit a variety of tumors and has no cross resistance with alkylating agents and purines.
Function and use
This product is a biological ester base with anticancer effect proposed from Cephalotaxus. It can inhibit the synthesis of proteins in eukaryotic cells and depolymerize polyribosomes. It is an anticancer drug that interferes with the function of protein synthesis. It is clinically used to treat acute promyelocytic leukemia, acute monocytic leukemia, acute myeloid leukemia and malignant lymphoma.
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