Genistein mainly exists in legumes, such as Sophora japonica and mountain bean roots. Genistein, i.e. genistein, is a rectangular or hexagonal rod-shaped crystal (60% ethanol), dendritic crystal (ether), melting point 297-298 ℃ (slightly decomposed). It is soluble in DMSO and ethanol, almost insoluble in water, and its solubility in water is 8.7 μ g / ml. changing the pH of the solution has no obvious effect on genistein.
Product use
It is used for anti-tumor, bacteriostasis, blood lipid lowering and estrogen like effects.
antitumor activity
Inhibit cell cycle: make cells stop and G2 / M phase; Inducing tumor cell apoptosis: Tongguang up regulates relevant Pro apoptotic genes and down regulates corresponding anti apoptotic genes to promote tumor cell apoptosis, so as to prevent and limit the occurrence of tumor;
Bacteriostasis
Its antibacterial mechanism is achieved by destroying the integrity of cell wall and cell membrane, inhibiting TCA cycle pathway and protein synthesis. This is consistent with Kim's view on the antibacterial mechanism of drugs [11]. Because genistein has physiological activities such as bacteriostasis and oxidation resistance, in terms of nutrition, if Gen is selected as food additive, it can play its dual role and has a very broad application prospect. [2]
Estrogen like effect
GEN (genistein or genistein) and its aglycones are the highest components in soybean isoflavones. The aglycones of soy isoflavones are more active than glycoside forms, especially GEN, which have higher activity of MCF-7 and have bidirectional regulation of phytoestrogens. ER cells are human breast cancer cell lines that can be specifically regulated by estrogen or estrogen like substances. 。 Estrogen like increment is very sensitive, simple and easy, and can also distinguish agonists and antagonists. Therefore, it is widely used to quickly screen and evaluate phytoestrogens of environmental estrogens.
Studies have reported that Gen can stimulate the expression of estrogen regulatory genes like estrogen, suggesting that Gen can bind to estrogen receptor, not only produce anti estrogen like effect, but also show certain estrogen effect by activating estrogen response elements.
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