Tadalafil, trade name: Cialis, is a long-acting phosphodiesterase 5 (PDE5) inhibitor developed by Eli Lilly for the treatment of male erectile dysfunction (ED).
Listed in the US in 2003, global sales in 2016 were $2.456 billion, and in 2017 it was $2,304 million.
According to the data from the intranet, in 2017, in the city public hospitals , county-level public hospitals, urban community centers, township health centers (referred to as China's public medical institutions) terminals and China's urban retail pharmacies terminal chemical drug market, Tadarafi The total sales exceeded 700 million yuan.
▍ED three main treatment drugs
The first-line treatment plan for ED is mainly oral drug therapy. The commonly used drug in clinical practice is type 5 phosphodiesterase inhibitor (PDE5). Currently, PDE5 inhibitors that have been marketed include sildenafil, tadalafil, and vardenafil. Wait.
(Source: Xinkang)
Applicable symptoms
Erectile dysfunction and pulmonary hypertension.
Usage and dosage
The recommended dose of this product is 10mg. It should be taken before having sex and is not affected by eating. If the effect of taking 10mg is not significant, you can take 20mg, at least 30 minutes before sex.
The maximum frequency of taking medicine was once a day.
taboo
Clinical studies have shown that tadalafil can enhance the antihypertensive effect of nitrate drugs. This is considered to be the result of the interaction of nitrates and tadalafil on the nitric oxide / cGMP pathway. Therefore, patients who are taking any form of nitrate drugs are forbidden to take this product.
Sex can bring potential heart risk to patients with heart disease. Therefore, erectile dysfunction drugs, including tadalafil, should not be used in heart disease patients who are not recommended to have sex. For patients with heart disease, doctors should consider the potential heart risk of sex. The following cardiovascular diseases are not included in the clinical trials conducted, so tadalafil is strictly prohibited in these people:
● patients with myocardial infarction in the last 90 days
Patients with unstable angina pectoris or angina pectoris during sexual intercourse
● heart failure patients with NYHA grade 2 or more in the past 6 months
Patients with refractory arrhythmia, hypotension (< 90 / 50mmhg), or refractory hypertension
● patients with stroke in the last 6 months
● do not take tadalafil if you are known to be allergic to tadalafil and the ingredients in its prescription
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