An important inhibitor of IL-1 in osteoarthritis ---- Diacerein Powder

March 04, 2022

Diacerein, also known as diacetyl dihydroanthracene carboxylic acid, daserein and ambidin, is a new interleukin (IL) - 1 inhibitor with the chemical name of diacetyl Rhein. It belongs to anthraquinone compounds. This product can induce the formation of cartilage chemicalbook, has analgesic, anti-inflammatory and antipyretic effects, and can also significantly improve the joint function of patients with osteoarthritis, delay the course of disease and reduce pain, It can improve the quality of life of patients and has good safety. Clinically, it is mainly used to treat osteoarthritis (OA) and play an antibacterial role.

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Solubility: easily soluble in dimethyl sulfoxide and dimethyl acetamide; Insoluble in water, methanol and chloroform.

Function

1. Inhibit the synthesis of IL-1 in synovial tissue.

2. Inhibit the expression of IL-1 receptor in chondrocytes.

3. Inhibit the activity of IL-1.

4. Inhibit the production of metalloproteinases and peroxides such as collagenase, chemicalbook and matrix lysin. 5. Promote the synthesis of collagen and aminopolysaccharide.

6. Inhibit the chemotaxis of leukocytes and stabilize lysosomes.

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Application

1. It is widely used in new liquid crystal polymers, high-strength fibers and engineering plastics with excellent properties.

2. An important inhibitor of IL-1 in osteoarthritis

3.Natural antioxidants can delay aging, enhance immunity, eliminate sub-health state, restore physical fitness, improve energy and body immunity.

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