5-hydroxytryptophan is an organic compound with molecular formula c11h12n2o3. It is an amino acid substance. It can be used as a precursor of serotonin in human body. Therefore, it is considered to help to improve the level of serotonin. However, its regulatory effect on sleep and therapeutic effect on depression are still controversial in academic circles.
5-hydroxytryptophan (5-HTP) is an amino acid substance. It can be used as a precursor of serotonin (serotonin, 5-HT) in human body (and then as a precursor of melatonin). Some double-blind studies have shown that 5-HTP can increase the concentration of brain serotonin, improve depression, promote the formation of melatonin, improve sleep quality and inhibit appetite, but there are still problems in these studies. Therefore, more studies are still needed to confirm whether 5-HTP has these physiological effects[ 1] Ghana seed is rich in 5-hydroxytryptophan, which is the main natural source of 5-HTP.
5-HTP is classified as a pharmaceutical ingredient in some countries. 5-HTP is sold as a dietary supplement (health product) in the United States, the United Kingdom and Canada. Physiological Function
Taking 5-HTP can be converted into serotonin in the body, but serotonin cannot enter the brain through the blood-brain barrier. Therefore, 5-HTP must first pass through the blood-brain barrier and then be converted into serotonin in the brain in order to really play the role of stabilizing mood and promoting sleep quality. After taking 5-HTP orally, only about one-third to one-half of it can be converted into serotonin in the brain, Most of them will be converted into serotonin before entering the blood circulation of the brain, and this part is a physiological effect without positive significance.
Many studies have pointed out that 5-HTP has certain physiological effects. According to clinical research, taking 5-HTP can significantly improve the mood of patients with depression. In addition, 5-HTP can also promote sleep quality and improve mild insomnia. In addition, clinical research evidence shows that 5-HTP can relieve pain, improve the discomfort of some patients with myofibrodynia, and also improve chronic stress headache. Clinical research has found that taking 5-HTP will reduce the frequency of recurrent headache and increase the concentration of enkephalin in the body. Enkephalin is a analgesic and happy substance naturally secreted by the human body, The increased concentration of enkephalin can make the human body feel comfortable and happy. Animal experiments also found that 5-HTP can increase the blood concentration of leptin, improve the control of appetite and avoid overeating. A clinical study on 19 obese women found that 8 mg (mg) of 5-HTP per kilogram of body weight was taken every day for five weeks, and the average weight decreased by 5% without dietary prescription, Similar results also appear in other clinical studies that are longer and for non-insulin-dependent diabetes mellitus. Therefore, 5-HTP can indeed be used as an adjunct to appetite control in obese people. However, it is worth noting that the strength of these evidences is still insufficient, and the physiological role of 5-HTP is still controversial.
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