1. What is Sophora Root extract?
Sophora flavescens extract is the extract of Sophora flavescens, the main effective component of oxymatrine content of more than 98%. It has the functions of clearing away heat and dampness, killing insects and diuresis. It is used for hot dysentery, bloody stool, jaundice, urination, red leucorrhea, Yin swelling and Yin itching, eczema, wet sore, skin itching, scabies and leprosy, and external treatment of trichomonal vaginitis.
2. Sophora Root extract benefits
1. Protection of gastric mucosa
Sophora flavescens extract has obvious protective effect on gastric mucosal damage caused by hydrochloric acid, ethanol and indomethacin. Its main component is flavanone compounds. Recent studies have shown that matrine is also one of the effective components of Sophora flavescens against gastric mucosal injury, and has a certain anti ulcer effect.
2. Anti inflammatory effect
Matrine has obvious antagonism against acute exudative inflammation caused by various inflammatory agents (croton oil, glacial acetic acid, carrageenan, egg white), which is similar to hydrocortisone. Its anti-inflammatory mechanism has nothing to do with the pituitary adrenal cortex system. Matrine still has a significant anti-inflammatory effect on adrenalectomy mice. Studies have shown that this product has the characteristics of non steroidal anti-inflammatory drugs. In addition, matrine has a stabilizing effect on erythrocyte membrane, and drugs that have a stabilizing effect on erythrocyte often have a stabilizing effect on lysosomal membrane, so as to reduce the release of inflammatory mediators and achieve the purpose of anti-inflammatory.
3. Leukocyte raising effect
Oxymatrine can prevent leukopenia in mice caused by MMC and cyclophosphamide. Intravenous or intramuscular injection of total matrine and Oxymatrine can significantly increase the number of leukocytes in peripheral blood of normal rabbits. Moreover, compared with total matrine, the significant effect time, maintenance time and peak value of leukocyte count of oxymatrine on normal rabbits are basically the same within 18 days after administration, The whitening effect is better than that of shark liver alcohol.
4. Effect on cardiovascular system
Intravenous injection of matrine and Oxymatrine significantly antagonized arrhythmias induced by aconitine and chloroform adrenaline in rats; Intraperitoneal injection significantly antagonized the ventricular fibrillation induced by chemicalbook chloroform in mice, increased the dosage of aconitine induced arrhythmias in rats, antagonized the arrhythmias induced by barium chloride in rats and ligated the anterior descending coronary artery in rats.
5. Antiasthmatic and expectorant effect
Matrine is mainly through excitement β Receptors, especially in the excitatory center β Receptor, which relieves bronchospasm and inhibits the release of antibodies and slow reactive substances to produce antiasthmatic effect.
6. Stabilizing effect
Total alkaloids of Sophora flavescens can significantly inhibit the free activity of mice; It significantly inhibited the passive activity of mice; High dose can inhibit the fighting and aggressive behavior of lonely mice.
7. Immunosuppression
Matrine and Oxymatrine can inhibit the immune function of mice.
8. Antifungal effect
Sophora flavescens decoction has inhibitory effect on common skin fungi.
9. Bacteriostasis
Sophora flavescens extract has inhibitory effect on Staphylococcus, Pseudomonas aeruginosa, Mycobacterium tuberculosis, etc.
10. Effect on central nervous system
When matrine was injected into rabbits, central nerve paralysis was found, and spasm occurred at the same time, and finally breathing stopped and died. When injected into frogs, they are initially excited, then paralyzed, and their breathing becomes slow and irregular. Later, spasms occur, resulting in respiratory arrest and death. The onset of spasms may be caused by hyperreflexia of the spinal cord.
11. Antiarrhythmic effect
Sophora flavescens has a good antagonistic effect on arrhythmias caused by aconitine, sympathetic amine and digitalis poisoning, and its effect is quite similar to quinidine. That is, by affecting the potassium and sodium conduction system of myocardial cell membrane, the absolute refractory period of myocardium is prolonged and the stress is reduced, so as to inhibit ectopic pacemaker and play an anti arrhythmic role. The active ingredient is initially proved to be the alkaloid contained. Because Sophora flavescens has no effect on myocardial contractility and heart rate of frog heart in vivo and rats, it does not increase myocardial oxygen consumption and aggravate heart failure and shock, which is worthy of attention for ischemic heart disease.
12. Toxic effects human oral
Excessive Sophora flavescens can cause poisoning, with symptoms such as salivation, irregular pace, accelerated breathing, accelerated pulse, convulsion, and finally death due to respiratory arrest. Rescue method: when there is no convulsion, you can wash the stomach, catharsis, take egg white, tannic acid, strong tea, intravenous drip of glucose saline. Spasmolytics such as phenobarbital are injected intramuscularly in case of convulsion, and respiratory stimulants are used in case of respiratory disorders.
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