Schisandra chinensis extract is the dry and mature fruit extract of Schisandra chinensis (Turcz.) Baill. Of Magnoliaceae plant. It has the effects of astringent and astringent, supplementing qi and promoting fluid, tonifying kidney and calming heart.
Active ingredient
The main active ingredients are lignans, such as DEOXYSCHIZANDRIN and schisandrin B( γ- Schizandrin), schizandrin, aomisin, pseudo-r-schizandrin, schizantherin a, etc. it also contains a variety of volatile oils such as pinene and organic acid compounds such as citric acid, malic acid and tartaric acid.
Main specifications
Schisandra a 2% - 5%, Schisandra chinensis total element 2% ~ 9%, Schisandra chinensis (b) B, Schisandra chinensis (a) a and Schisandra chinensis alcohol a
Pharmacological Action
Astringe the lung and nourish the kidney, generate saliva and sweat, astringe essence, stop bleeding, calm the heart and calm the mind. Replenish qi and nourish body fluid, tonify kidney 1653, nourish heart, astringent and astringent. It is used for wheezing and coughing due to lung deficiency and generating fluid
Clinical Application
It is used for chronic cough, asthenia and asthma, nocturnal ejaculation, frequent enuresis, persistent diarrhea, spontaneous sweating, night sweating, fluid injury, thirst, deficiency of short Qi and pulse, internal heat and thirst elimination, palpitation and insomnia. Deficiency, thirst, spontaneous sweating, chronic diarrhea, neurasthenia and other diseases.
Extraction Method
Take the medicinal materials, boil them in water, filter and obtain the drug residue → extract them with 80% ethanol, filter them → volatilize the alcohol in the filtrate, precipitate them with water → take the precipitate, extract them in gasoline and 80% ethanol → concentrate ethanol → crystallize.
Research Application
Schisandra chinensis is an astringent drug of traditional Chinese medicine, but the clinical observation in recent 20 years shows that Schisandra chinensis has a good 4102 therapeutic effect on hepatitis.
(l) Schisandra chinensis can significantly reduce the level of serum alanine aminotransferase in patients with hepatitis B. Its mechanism is to inhibit the synthesis of enzymes by hepatocytes, which has no obvious effect on normal liver, and even inhibit the activity of enzymes in injured liver.
(2) It can improve systemic symptoms, such as loss of appetite, fatigue, insomnia, etc. 2113 can protect the liver, promote hepatocyte regeneration, enhance liver detoxification function and adrenal cortex function, so as to restore liver function.
Liu gengtao, a researcher in the second Department of pharmacology, Institute of pharmacy, Chinese Academy of Medical Sciences and academician of Chinese Academy of engineering, has been the first to open up the research field of liver biochemical pharmacology in China since the 1970s. He has focused on Chinese herbal medicine, and has successively carried out systematic research on the pharmacological effects of Schisandra chinensis, Ganoderma lucidum, yellow bark leaf, tetrahydroxanthine and other anti hepatocyte damage, These compounds were found to have many unique pharmacological activities. In terms of research on anti hepatitis drugs, he chose the liver as the target organ of "Fuzheng Guben" traditional Chinese medicine from the practice of Chinese herbal medicine research, and studied with colleagues of the research group. First, he proved that a variety of components in Schisandra chinensis can protect the liver from some chemical poisons and antagonize oxygen free radical damage, Stimulate liver anabolism and enhance the activity of cytochrome P450. In cooperation with pharmaceutical, chemical and pharmacological experts, he found that its analog biphenyl diester (produced by Beijing Xiehe pharmaceutical factory) has obvious effects of reducing transaminase and protecting liver on the basis of synthesizing schisandrin C.
The development and application of Schisandra chinensis is also mainly focused on new drugs for the treatment of hepatitis.
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