Myricetin, also known as myricetin and myricetin, is a flavonol extracted from the bark of myricetin, a plant of myriaceae.
The bark of Myrica rubra is used as an antibacterial and anti-inflammatory drug in the folk. The bark of Myrica rubra mainly contains myricetin and myricetin glycosides. In recent years, studies at home and abroad have shown that myricetin has a variety of activities: antagonistic effect of platelet activating factor (PAF), hypoglycemic effect, Antioxidant effect, liver protective effect of chemical book, relieving light ethanol poisoning, myricetin, the active ingredient in myricetin bark and leaves, in addition to the above verified pharmacological effects, it also has anti-inflammatory, anti-tumor, anti mutation It has many pharmacological activities, such as preventing dental caries, antioxidation, eliminating free radicals in the body and so on.
Main functions of myricetin:
1) antioxidant effect: myricetin is a strong antioxidant. Oxidative stress plays a key role in various neurological diseases, including local ischemia and senile dementia. Myricetin is reduced by conformational change β- The production and toxicity of amylase can be used to count the progress of Alzheimer's disease.
2) Antitumor effect: myricetin is an effective chemical preventive agent against carcinogenesis.
3) Reduce neurotoxicity: myricetin can inhibit neurotoxicity caused by glutamate in different ways, protect neurons, and effectively prevent nerve injury.
4) Effects on lymphocyte activation and proliferation: myricetin can inhibit the expression of CD69, an early activation index of T cells, and inhibit the lymphocyte proliferation reaction produced by chemicalbook.
5) Antagonism of platelet activating factor (PAF): myricetin inhibited PAF induced WRP aggregation and 52ht release in a concentration dependent manner in vitro. At the same time, it can significantly inhibit the increase of free calcium in platelets caused by PAF. Therefore, myricetin has many cardiovascular pharmacological effects, such as antithrombotic, anti myocardial ischemia, improving microcirculation and so on.
6) Hypoglycemic effect: myricetin has obvious hypoglycemic effect.
7) Effect of protecting liver and protecting liver: dihydromyricetin can significantly inhibit the increase of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities in serum and reduce serum total bilirubin, and has an obvious effect of reducing enzyme and yellowing.
Purpose
For inflammation, diabetes and cancer research. It is a non ATP competitive MEK-1 inhibitor.
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