Genistein is light yellow crystalline powder; It has the properties of estrogen and anti estrogen, has Antioxidant effect, can inhibit the activity of tyrosine protein kinase (PTK), can inhibit the activity of topoisomerase II, has the functions of inducing programmed cell death, improving anti-cancer efficacy, inhibiting angiogenesis, etc. It is a potential cancer chemopreventive agent, and its anti-cancer effect and mechanism have broad application prospects.
Genistein, also known as genistein, is a polyphenol compound found in plants such as soybean and red clover, with a molecular structure similar to 17 β- Estradiol, with antioxidation and high affinity for estrogen receptor, can inhibit the activities of tyrosine protein kinase (PTK) and topoisomerase II, and has the effects of inducing programmed cell death, improving anti-cancer efficacy, inhibiting angiogenesis, etc. It is a type of flavonoids (also called isoflavones). It is often found together with isoflavones called daidzein, which are called soybean isoflavones. The benefits of these compounds on human health have been widely studied, and they are potential cancer chemopreventive agents, which have significant effects on the prevention of cancer and other diseases. Genistein is the main phytoestrogen studied at present.
Plant source: Leguminous plant dyewood (broom).
Genistein has a polyphenol hydroxy structure. The hydrogen atom on the phenol hydroxy is easy to separate from the oxygen atom under external action to form hydrogen ions and play a reducing effect. This is the structural basis for genistein to be able to resist oxidation and have reducibility. Therefore, such substances in food can fight against superoxide anion free radicals, block the chain reaction of free radicals, and play an antioxidant role.
Genistein is not a hormone, but it is called phytoestrogen because it can combine with estrogen receptor to play a weak estrogen effect. Since the activity of isoflavone is 1/1000 of estradiol, it competitively binds with estradiol to estrogen receptor, showing a two-way regulatory effect, and the resulting estrogen effect is much lower than the harmful effect of estradiol, thus it has a protective effect on hormone related diseases, such as menopause syndrome, osteoporosis, blood lipid elevation, etc; For those with high estrogen level, it has anti estrogen activity, can prevent and treat breast cancer and endometritis, and has two-way regulation and balance function.
Purpose
1. It has estrogen and anti estrogen properties
2. In vivo, it can inhibit colon cancer, breast cancer, skin cancer, prostate cancer, etc
3. It has inhibitory effect on many tumor cell lines
4. It has antioxidant effect
5. It can inhibit the activity of tyrosine protein kinase (PTK)
6. It can inhibit the activity of topoisomerase II
7. It can prevent postmenopausal osteoporosis
8. It can induce programmed cell death, improve anti-cancer efficacy, inhibit angiogenesis, etc. It is a potential cancer chemopreventive agent. Its anti-cancer effect and mechanism have broad application prospects.
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